Comparative in vitro and in vivo assessment of three experimental extracellular matrix meshes for soft tissue remodeling.

Abstract

The development of standardized cross-species evaluation frameworks is urgently needed for absorbable extracellular matrix (ECM) meshes, due to significant variations in safety and efficacy across tissue sources. This study establishes a multi-dimensional assessment system to quantify material-specific bio-functional correlations. Three ECM meshes-human acellular dermis (HAD), porcine acellular dermis (PAD), and porcine small intestinal submucosa (SIS)-were systematically characterized using int